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Literature summary for 3.4.21.37 extracted from

  • Fu, Z.; Thorpe, M.; Akula, S.; Chahal, G.; Hellman, L.T.
    Extended cleavage specificity of human neutrophil elastase, human proteinase 3, and their distant ortholog clawed frog PR3 - three elastases with similar primary but different extended specificities and stability (2018), Front. Immunol., 9, 2387 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.37

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme prefers L-Val in the P1 position but also cleaves substrates with L-Ile relatively efficiently and does not cleave after aromatic amino acids ?
-
 ?
additional information Homo sapiens the protease shows self-cleaving activity ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293-EBNA cell
-
 Homo sapiens
-
neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GRGGAGGRG + H2O
-
 Homo sapiens GRGGA + GGRG
-
 ?
GRGGFGGRG + H2O
-
 Homo sapiens GRGGF + GGRG
-
 ?
GRGGLGGRG + H2O
-
 Homo sapiens GRGGL + GGRG
-
 ?
GRGGRGGRG + H2O
-
 Homo sapiens GRGGR + GGRG
-
 ?
GRGGVGGRG + H2O
-
 Homo sapiens GRGGV + GGRG
-
 ?
additional information the enzyme prefers L-Val in the P1 position but also cleaves substrates with L-Ile relatively efficiently and does not cleave after aromatic amino acids Homo sapiens ?
-
 ?
additional information the protease shows self-cleaving activity Homo sapiens ?
-
 ?
additional information no activity with succiny-Ala-Ala-Pro-Phe-4-nitroanilide, succiny-Leu-Leu-Val-Tyr-4-nitroanilide, succiny-Ala-Ala-Pro-Leu-4-nitroanilide, succiny-Val-Leu-Gly-Arg-4-nitroanilide, Z-Gly-Pro-Arg-4-nitroanilide, acetyl-Tyr-Val-Ala-Asp-4-nitroanilide, acetyl-Val-Glu-Ile-Asp-4-nitroanilide, and acetyl-Ile-Glu-Pro-Asp-4-nitroanilide Homo sapiens ?
-
 ?
succinyl-Ala-Ala-Pro-Ala-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
succinyl-Ala-Ala-Pro-Ile-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
succinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
VLLFSEVL + H2O
-
 Homo sapiens VLLF + SEVL
-
 ?
VLLISEVL + H2O
-
 Homo sapiens VLLI + SEVL
-
 ?
VLLVSEVL + H2O
-
 Homo sapiens VLLV + SEVL
-
 ?

Subunits

Subunits Comment Organism
? x * 30000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
HNE
-
 Homo sapiens
N-elastase
-
 Homo sapiens
neutrophil elastase
-
 Homo sapiens