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Literature summary for 3.4.21.37 extracted from

  • Hochscherf, J.; Pietsch, M.; Tieu, W.; Kuan, K.; Abell, A.D.; Guetschow, M.; Niefind, K.
    Crystal structure of highly glycosylated human leukocyte elastase in complex with an S2 site binding inhibitor (2018), Acta Crystallogr. Sect. F, 74, 480-489 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.37

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with 1a, sitting drop vapor diffusion method, using 20% (w/v) PEG MME 5000, 0.2 M sodium sulfate Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N2-[4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzoyl]-N-(2-propylphenyl)-L-leucinamide
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P08246
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
 Homo sapiens methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
 ?

Subunits

Subunits Comment Organism
? x * 29500, SDS-Page Homo sapiens
? x * 23224 calculated from amino acid sequence Homo sapiens

Synonyms

Synonyms Comment Organism
HLE
-
 Homo sapiens
HNE
-
 Homo sapiens
neutrophil elastase
-
 Homo sapiens