Literature summary for 3.4.21.37 extracted from

Nogami, K.; Ogiwara, K.; Matsumoto, T.; Nishiya, K.; Takeyama, M.; Shima, M.
Mechanisms of human neutrophil elastase-catalysed inactivation of factor VIII(a) (2011), Thromb. Haemost., 105, 968-980.

Search for more literature for 3.4.21.37

Inhibitors

Inhibitors	Comment	Organism	Structure
MeOSuc-Ala-Ala-Pro-Val-chloromethylketone	neutrophil elastase-specific inhibitor	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Factor VIIIa + H2O	Homo sapiens	neutrophil elastase inactivates factor VIIIa. The enzyme proteolyses the heavy chain of factor VIIIa into two terminal products, A11-358 and A2375-708, by limited proteolysis at Val358, Val374, and Val708	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Factor VIIIa + H2O	neutrophil elastase inactivates factor VIIIa. The enzyme proteolyses the heavy chain of factor VIIIa into two terminal products, A11-358 and A2375-708, by limited proteolysis at Val358, Val374, and Val708	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
HNE	-	Homo sapiens
neutrophil elastase	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)