Inhibitors | Comment | Organism | Structure |
---|---|---|---|
elafin | complete inhibition at 0.01 mM | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
proteinase-activated receptor 2 N-terminus + H2O | Homo sapiens | - |
GPNSKGRSLIGRLDTPPPITGKGAPVEPGFSVDEFSAS + VLTGKLTTVFLP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
methoxysuccinyl-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | methoxysuccinyl-Ala-Ala-Pro-Val + 7-amino-4-methylcoumarin | - |
? | |
proteinase-activated receptor 2 N-terminus + H2O | - |
Homo sapiens | GPNSKGRSLIGRLDTPPPITGKGAPVEPGFSVDEFSAS + VLTGKLTTVFLP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
neutrophil elastase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | neutrophil elastase acts as a biased agonist for proteinase-activated receptor 2. Neutrophil elastase causes a tethered ligand-independent proteinase-activated receptor 2-mediated activation of MAPK that does not involve either receptor internalization or recruitment of beta-arrestin. The enzyme can disarm proteinase-activated receptor 2-dependent calcium responses to trypsin | Homo sapiens |