Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3-methylindazol-1-yl)-m-tolyl-methanone | - |
Homo sapiens | |
1-(2-methylbenzoyl)-1H-indazole-3-carboxylic acid phenylamide | - |
Homo sapiens | |
1-(3-aminobenzoyl)-1H-indazole-3-carboxylic acid ethyl ester | - |
Homo sapiens | |
1-(3-aminobenzoyl)-1H-indazole-3-carboxylic acid phenylamide | - |
Homo sapiens | |
1-(3-methoxybenzoyl)-1H-indazole-3-carboxylic acid ethyl ester | - |
Homo sapiens | |
1-(3-methoxybenzoyl)-1H-indazole-3-carboxylic acid methyl ester | - |
Homo sapiens | |
1-(3-methoxybenzoyl)-1H-indazole-3-carboxylic acid phenylamide | - |
Homo sapiens | |
1-(3-methoxybenzoyl)-1H-indazole-3-carboxylic acid propyl ester | - |
Homo sapiens | |
1-(3-methylbenzoyl)-1H-indazole-3-carboxylic acid methyl ester | - |
Homo sapiens | |
1-(4-cyanobenzoyl)-1H-indazole-3-carboxylic acid ethyl ester | - |
Homo sapiens | |
1-(pyridine-4-carbonyl)-1H-indazole-3-carboxylic acid phenylamide | - |
Homo sapiens | |
1-(thiophene-3-carbonyl)-1H-indazole-3-carboxylic acid ethyl ester | - |
Homo sapiens | |
1-(thiophene-3-carbonyl)-1H-indazole-3-carboxylic acid methyl ester | - |
Homo sapiens | |
1-(thiophene-3-carbonyl)-1H-indazole-3-carboxylic acid phenylamide | - |
Homo sapiens | |
1-(thiophene-3-carbonyl)-1H-indazole-3-carboxylic acid propyl ester | - |
Homo sapiens | |
1-benzoyl-1H-indazole-3-carboxylic acid methyl ester | - |
Homo sapiens | |
1-benzoyl-1H-indazole-3-carboxylic acid phenylamide | - |
Homo sapiens | |
1-butyryl-1H-indazole-3-carboxylic acid ethyl ester | - |
Homo sapiens | |
1-cyclopentanecarbonyl-1H-indazole-3-carboxylic acid ethyl ester | - |
Homo sapiens | |
1-propionyl-1H-indazole-3-carboxylic acid ethyl ester | - |
Homo sapiens | |
1-[(3-chlorophenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide | - |
Homo sapiens | |
1-[(3-fluorophenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide | - |
Homo sapiens | |
1-[(3-methylphenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide | - |
Homo sapiens | |
1-[(3-nitrophenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide | - |
Homo sapiens | |
1-[(4-chlorophenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide | - |
Homo sapiens | |
1-[(4-cyanophenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide | - |
Homo sapiens | |
1-[(4-fluorophenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide | - |
Homo sapiens | |
1-[(4-methylphenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide | - |
Homo sapiens | |
1H-indazol-1-yl(3-methylphenyl)methanone | - |
Homo sapiens | |
2,2,2-trifluoroethyl 1-(phenylcarbonyl)-1H-indazole-3-carboxylate | - |
Homo sapiens | |
2,2,2-trifluoroethyl 1-(thiophen-3-ylcarbonyl)-1H-indazole-3-carboxylate | - |
Homo sapiens | |
2,2,2-trifluoroethyl 1-[(3-aminophenyl)carbonyl]-1H-indazole-3-carboxylate | - |
Homo sapiens | |
2,2,2-trifluoroethyl 1-[(3-methoxyphenyl)carbonyl]-1H-indazole-3-carboxylate | - |
Homo sapiens | |
2,2,2-trifluoroethyl 1-[(3-methylphenyl)carbonyl]-1H-indazole-3-carboxylate | - |
Homo sapiens | |
ethyl 1-(1,3-benzodioxol-5-ylcarbonyl)-1H-indazole-3-carboxylate | - |
Homo sapiens | |
ethyl 1-(phenylcarbonyl)-1H-indazole-3-carboxylate | - |
Homo sapiens | |
ethyl 1-acetyl-1H-indazole-3-carboxylate | - |
Homo sapiens | |
ethyl 1-[(2-methylphenyl)carbonyl]-1H-indazole-3-carboxylate | - |
Homo sapiens | |
ethyl 1-[(3-chlorophenyl)carbonyl]-1H-indazole-3-carboxylate | - |
Homo sapiens | |
ethyl 1-[(3-fluorophenyl)carbonyl]-1H-indazole-3-carboxylate | - |
Homo sapiens | |
ethyl 1-[(3-methylphenyl)carbonyl]-1H-indazole-3-carboxylate | - |
Homo sapiens | |
ethyl 1-[(4-chlorophenyl)carbonyl]-1H-indazole-3-carboxylate | - |
Homo sapiens | |
ethyl 1-[(4-fluorophenyl)carbonyl]-1H-indazole-3-carboxylate | - |
Homo sapiens | |
ethyl 1-[(4-methylphenyl)carbonyl]-1H-indazole-3-carboxylate | - |
Homo sapiens | |
additional information | not inhibited by 1-(3-methylbenzoyl)-1H-indazole-3-carboxylic acid, (3-methoxyphenyl)-(3-methylindazol-1-yl)-methanone, 1-(pyridine-4-carbonyl)-1H-indazole-3-carboxylic acid ethyl ester, 1-(naphthalene-1-carbonyl)-1H-indazole-3-carboxylic acid ethyl ester, 1-(3,4,5-trimethoxybenzoyl)-1H-indazole-3-carboxylic acid ethyl ester, 1-(pyridine-4-carbonyl)-1H-indazole-3-carboxylic acid phenylamide, 1-(toluene-4-sulfonyl)-1H-indazole-3-carboxylic acid phenylamide, 1-(4-chlorobenzenesulfonyl)-1H-indazole-3-carboxylic acid phenylamide, 1-(4-chlorobenzyl)-1H-indazole-3-carboxylic acid phenylamide, 1-(4-chlorophenyl)-1H-indazole-3-carboxylic acid phenylamide, 1-(2-oxo-2-phenylethyl)-1H-indazole-3-carboxylic acid ethyl ester, 1-(4-chlorophenylcarbamoyl)-1H-indazole-3-carboxylic acid ethyl ester, and 1-(3-methoxyphenylcarbamoyl)-1H-indazole-3-carboxylic acid ethyl ester | Homo sapiens | |
propan-2-yl 1-(phenylcarbonyl)-1H-indazole-3-carboxylate | - |
Homo sapiens | |
propan-2-yl 1-(thiophen-3-ylcarbonyl)-1H-indazole-3-carboxylate | - |
Homo sapiens | |
propan-2-yl 1-[(3-aminophenyl)carbonyl]-1H-indazole-3-carboxylate | - |
Homo sapiens | |
propan-2-yl 1-[(3-methoxyphenyl)carbonyl]-1H-indazole-3-carboxylate | - |
Homo sapiens | |
propan-2-yl 1-[(3-methylphenyl)carbonyl]-1H-indazole-3-carboxylate | - |
Homo sapiens | |
propyl 1-(phenylcarbonyl)-1H-indazole-3-carboxylate | - |
Homo sapiens | |
propyl 1-[(3-aminophenyl)carbonyl]-1H-indazole-3-carboxylate | - |
Homo sapiens | |
propyl 1-[(3-methylphenyl)carbonyl]-1H-indazole-3-carboxylate | - |
Homo sapiens | |
sivelestat | ONO-5046, competitive and selective inhibitor | Homo sapiens |
Organic Solvent | Comment | Organism |
---|---|---|
DMSO | 1% (v/v) DMSO has no effect on enzyme activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-methoxysuccinyl-L-Ala-L-Ala-L-Pro-L-Val-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | N-methoxysuccinyl-L-Ala-L-Ala-L-Pro-L-Val + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HNE | - |
Homo sapiens |
neutrophil elastase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000089 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1-benzoyl-1H-indazole-3-carboxylic acid methyl ester | |
0.00013 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1-(3-methylbenzoyl)-1H-indazole-3-carboxylic acid methyl ester | |
0.00018 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1-butyryl-1H-indazole-3-carboxylic acid ethyl ester | |
0.00024 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | propan-2-yl 1-(phenylcarbonyl)-1H-indazole-3-carboxylate | |
0.00026 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 2,2,2-trifluoroethyl 1-(phenylcarbonyl)-1H-indazole-3-carboxylate | |
0.00031 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1-(thiophene-3-carbonyl)-1H-indazole-3-carboxylic acid methyl ester | |
0.00034 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 2,2,2-trifluoroethyl 1-[(3-aminophenyl)carbonyl]-1H-indazole-3-carboxylate | |
0.0004 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | ethyl 1-(phenylcarbonyl)-1H-indazole-3-carboxylate | |
0.0004 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | propyl 1-(phenylcarbonyl)-1H-indazole-3-carboxylate | |
0.0004 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1-propionyl-1H-indazole-3-carboxylic acid ethyl ester | |
0.00041 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | ethyl 1-[(3-methylphenyl)carbonyl]-1H-indazole-3-carboxylate | |
0.00042 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1-benzoyl-1H-indazole-3-carboxylic acid phenylamide | |
0.00046 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 2,2,2-trifluoroethyl 1-[(3-methylphenyl)carbonyl]-1H-indazole-3-carboxylate | |
0.00048 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1-cyclopentanecarbonyl-1H-indazole-3-carboxylic acid ethyl ester | |
0.00051 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | propan-2-yl 1-[(3-aminophenyl)carbonyl]-1H-indazole-3-carboxylate | |
0.00051 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 2,2,2-trifluoroethyl 1-(thiophen-3-ylcarbonyl)-1H-indazole-3-carboxylate | |
0.00055 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1-(3-methoxybenzoyl)-1H-indazole-3-carboxylic acid methyl ester | |
0.00065 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | propan-2-yl 1-[(3-methylphenyl)carbonyl]-1H-indazole-3-carboxylate | |
0.00069 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | propan-2-yl 1-(thiophen-3-ylcarbonyl)-1H-indazole-3-carboxylate | |
0.0007 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | propyl 1-[(3-aminophenyl)carbonyl]-1H-indazole-3-carboxylate | |
0.00076 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | propan-2-yl 1-[(3-methoxyphenyl)carbonyl]-1H-indazole-3-carboxylate | |
0.00078 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | propyl 1-[(3-methylphenyl)carbonyl]-1H-indazole-3-carboxylate | |
0.0008 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1-(3-methoxybenzoyl)-1H-indazole-3-carboxylic acid ethyl ester | |
0.00089 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 2,2,2-trifluoroethyl 1-[(3-methoxyphenyl)carbonyl]-1H-indazole-3-carboxylate | |
0.00093 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1-(thiophene-3-carbonyl)-1H-indazole-3-carboxylic acid ethyl ester | |
0.0016 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1-(3-aminobenzoyl)-1H-indazole-3-carboxylic acid ethyl ester | |
0.0017 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | ethyl 1-[(3-chlorophenyl)carbonyl]-1H-indazole-3-carboxylate | |
0.0017 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | ethyl 1-[(3-fluorophenyl)carbonyl]-1H-indazole-3-carboxylate | |
0.0018 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1-(3-methoxybenzoyl)-1H-indazole-3-carboxylic acid phenylamide | |
0.0019 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1-(3-methoxybenzoyl)-1H-indazole-3-carboxylic acid propyl ester | |
0.0019 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1-(thiophene-3-carbonyl)-1H-indazole-3-carboxylic acid propyl ester | |
0.0031 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1-(thiophene-3-carbonyl)-1H-indazole-3-carboxylic acid phenylamide | |
0.0031 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1-(3-aminobenzoyl)-1H-indazole-3-carboxylic acid phenylamide | |
0.0039 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1-[(3-chlorophenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide | |
0.0048 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | ethyl 1-acetyl-1H-indazole-3-carboxylate | |
0.0057 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | ethyl 1-[(4-fluorophenyl)carbonyl]-1H-indazole-3-carboxylate | |
0.0059 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1-[(3-fluorophenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide | |
0.0061 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1-[(4-chlorophenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide | |
0.0081 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1-[(4-fluorophenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide | |
0.0093 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1-[(3-methylphenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide | |
0.01 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1H-indazol-1-yl(3-methylphenyl)methanone | |
0.011 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1-[(3-nitrophenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide | |
0.019 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | ethyl 1-[(4-chlorophenyl)carbonyl]-1H-indazole-3-carboxylate | |
0.022 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | (3-methylindazol-1-yl)-m-tolyl-methanone | |
0.028 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | ethyl 1-(1,3-benzodioxol-5-ylcarbonyl)-1H-indazole-3-carboxylate | |
0.029 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1-[(4-methylphenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide | |
0.034 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1-(2-methylbenzoyl)-1H-indazole-3-carboxylic acid phenylamide | |
0.036 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | ethyl 1-[(4-methylphenyl)carbonyl]-1H-indazole-3-carboxylate | |
0.038 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1-[(4-cyanophenyl)carbonyl]-N-phenyl-1H-indazole-3-carboxamide | |
0.038 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | 1-(4-cyanobenzoyl)-1H-indazole-3-carboxylic acid ethyl ester | |
0.052 | - |
in 200 mM Tris-HCl, pH 7.5, at 25°C | Homo sapiens | ethyl 1-[(2-methylphenyl)carbonyl]-1H-indazole-3-carboxylate |