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Literature summary for 3.4.21.37 extracted from

  • Uchida, Y.; Freitas, M.C.; Zhao, D.; Busuttil, R.W.; Kupiec-Weglinski, J.W.
    The inhibition of neutrophil elastase ameliorates mouse liver damage due to ischemia and reperfusion (2009), Liver Transpl., 15, 939-947.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.37

Application

Application Comment Organism
medicine targeting neutrophil elastase represents a useful approach for preventing liver ischemia/reperfusion injury and hence expanding the organ donor pool and improving the overall success of liver transplantation Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information neutrophil elastase inhibitor treatment ameliorated hepatocellular damage and decreased local neutrophil infiltration, as assessed by myeloperoxidase assay, naphthol AS-D chloroacetate esterase stains, and immunohistochemistry. Expression of pro-inflammatory cytokines and chemokines is reduced, overview Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 male C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
liver middle hepatoc lobe Mus musculus
-
neutrophil
-
 Mus musculus
-
serum
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
 Mus musculus N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
neutrophil elastase
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Mus musculus

General Information

General Information Comment Organism
malfunction inhibition of neutrophil elastase ameliorates mouse liver damage due to ischemia and reperfusion, overview Mus musculus
physiological function a putative role of NE in the toll-like receptor 4, TLR4, signal transduction pathway Mus musculus