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Literature summary for 3.4.21.37 extracted from

  • Thongyoo, P.; Bonomelli, C.; Leatherbarrow, R.J.; Tate, E.W.
    Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold (2009), J. Med. Chem., 52, 6197-6200.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
MCoTI-II K10A a MCoTI-II exchange analogue Homo sapiens
MCoTI-II K10F a MCoTI-II exchange analogue Homo sapiens
MCoTI-II K10V a MCoTI-II exchange analogue Homo sapiens
additional information MCoTI-II modification and engineering by active site loop exchanges and truncations develop analogues with potent activity against leukocyte elastase, overview. No inhibition by MCoTI-I and MCoTI-II, and by analogues MCoTI-II K10R, MCoTI-II K10Q, and by MCoTI-II truncation analogues Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000021
-
 MCoTI-II K10V pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.000032
-
 MCoTI-II K10A pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0075
-
 MCoTI-II K10F pH not specified in the publication, temperature not specified in the publication Homo sapiens