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Literature summary for 3.4.21.37 extracted from

  • Weldon, S.; McNally, P.; McElvaney, N.G.; Elborn, J.S.; McAuley, D.F.; Wartelle, J.; Belaaouaj, A.; Levine, R.L.; Taggart, C.C.
    Decreased levels of secretory leucoprotease inhibitor in the Pseudomonas-infected cystic fibrosis lung are due to neutrophil elastase degradation (2009), J. Immunol., 183, 8148-8156.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted into the bronchoalveolar lavage fluid in the lung Homo sapiens
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-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
secretory leucoprotease inhibitor + H2O Homo sapiens i.e. SLPI, SLPI is cleaved and inactivated by neutrophil elastase in cystic fibrosis lungs ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information Pseudomonas aeruginosa-positive cystic fibrosis bronchoalveolar lavage fluid contains lower neutrophil serine protease inhibitor SLPI levels and higher neutrophil elastase activity compared to Pseudomonas aeruginosa-negative samples Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
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Homo sapiens N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
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?
secretory leucoprotease inhibitor + H2O i.e. SLPI, SLPI is cleaved and inactivated by neutrophil elastase in cystic fibrosis lungs Homo sapiens ?
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?
secretory leucoprotease inhibitor + H2O i.e. SLPI, recombinant human, a neutrophil serine protease inhibitor, neutrophil elastase cleaves the protein at two sites in the NH2-terminal region and abrogate its ability to bind lipopolysaccharides and NF-kappaB consensus binding sites but not its ability to inhibit activity of the serine protease cathepsin G Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
neutrophil elastase
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Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens