Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is secreted into the bronchoalveolar lavage fluid in the lung | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
secretory leucoprotease inhibitor + H2O | Homo sapiens | i.e. SLPI, SLPI is cleaved and inactivated by neutrophil elastase in cystic fibrosis lungs | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | Pseudomonas aeruginosa-positive cystic fibrosis bronchoalveolar lavage fluid contains lower neutrophil serine protease inhibitor SLPI levels and higher neutrophil elastase activity compared to Pseudomonas aeruginosa-negative samples | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O | - |
Homo sapiens | N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline | - |
? | |
secretory leucoprotease inhibitor + H2O | i.e. SLPI, SLPI is cleaved and inactivated by neutrophil elastase in cystic fibrosis lungs | Homo sapiens | ? | - |
? | |
secretory leucoprotease inhibitor + H2O | i.e. SLPI, recombinant human, a neutrophil serine protease inhibitor, neutrophil elastase cleaves the protein at two sites in the NH2-terminal region and abrogate its ability to bind lipopolysaccharides and NF-kappaB consensus binding sites but not its ability to inhibit activity of the serine protease cathepsin G | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
neutrophil elastase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |