Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | neutrophil elastase induces NF-kappaB activation by p65 in airway smooth muscle, which leads to induction of TGF-beta1. Neutrophil elastase suppresses NF-kappaB response gene IL-8/CXCL8 release and mRNA expression in airway smooth muscle cells at the transcription level mediated by induction of NF-kappaB repressing factor, NRF. In A549 and Beas-2B cells, neutrophil elastase only stimulates NF-kappaB activation by p65 and IL-8/CXCL8 induction, but not NRF, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | - |
Homo sapiens | - |
neutrophil | - |
Homo sapiens | - |
respiratory smooth muscle | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | neutrophil elastase induces NF-kappaB activation by p65 in airway smooth muscle, which leads to induction of TGF-beta1. Neutrophil elastase suppresses NF-kappaB response gene IL-8/CXCL8 release and mRNA expression in airway smooth muscle cells at the transcription level mediated by induction of NF-kappaB repressing factor, NRF. In A549 and Beas-2B cells, neutrophil elastase only stimulates NF-kappaB activation by p65 and IL-8/CXCL8 induction, but not NRF, overview | Homo sapiens | ? | - |
? | |
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O | - |
Homo sapiens | N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
neutrophil elastase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |