Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | inhibition of human SP-D protein cleavage at physiological concentrations | Pseudomonas aeruginosa |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | inhibition of SP-D protein cleavage at physiological concentrations | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
human SP-D protein + H2O | Pseudomonas aeruginosa | cleavage in the lungs of the cystic fibrosis human host, but not in helathy human hosts | SP-D protein peptide fragments | cleavage product identification by N-terminal sequencing, overview | ? | |
SP-D protein + H2O | Homo sapiens | no activity in healthy lungs, but in 50% of cystic fibrosis patient lungs | SP-D protein peptide fragments | cleavage product identification by N-terminal sequencing, overview | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Pseudomonas aeruginosa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bronchoalveolar lavage | of cystic fibrosis patients | Homo sapiens | - |
lung | the enzyme is commonly found in the lungs of cystic fibrosis patients | Homo sapiens | - |
additional information | the enzyme is commonly found in the bronchioalveolar lavage fluid of lungs of human cystic fibrosis patients, not of healthy human lungs | Pseudomonas aeruginosa | - |
neutrophil | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
human SP-D protein + H2O | - |
Pseudomonas aeruginosa | SP-D protein peptide fragments | cleavage product identification by N-terminal sequencing, overview | ? | |
human SP-D protein + H2O | cleavage in the lungs of the cystic fibrosis human host, but not in helathy human hosts | Pseudomonas aeruginosa | SP-D protein peptide fragments | cleavage product identification by N-terminal sequencing, overview | ? | |
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O | - |
Homo sapiens | N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline | - |
? | |
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O | - |
Pseudomonas aeruginosa | N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline | - |
? | |
SP-D protein + H2O | - |
Homo sapiens | SP-D protein peptide fragments | cleavage product identification by N-terminal sequencing, overview | ? | |
SP-D protein + H2O | no activity in healthy lungs, but in 50% of cystic fibrosis patient lungs | Homo sapiens | SP-D protein peptide fragments | cleavage product identification by N-terminal sequencing, overview | ? |
Synonyms | Comment | Organism |
---|---|---|
elastase | - |
Pseudomonas aeruginosa |
neutrophil elastase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Pseudomonas aeruginosa |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
7.5 | - |
assay at | Pseudomonas aeruginosa |