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Literature summary for 3.4.21.37 extracted from

  • Suzuki, T.; Yamashita, C.; Zemans, R.L.; Briones, N.; Van Linden, A.; Downey, G.P.
    Leukocyte elastase induces lung epithelial apoptosis via a PAR-1-, NF-kappaB-, and p53-dependent pathway (2009), Am. J. Respir. Cell Mol. Biol., 41, 742-755.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens leukocyte elastase induces binding activity of NF-kappaB to lung epithelial cells, and induces phosphorylation of p53 on Ser46 and alters its localization. And leukocyte elastase induces expression of PUMA, a p53-upregulated modulator of apoptosis ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
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Homo sapiens
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epithelial cell primary small airway epithelial cells Homo sapiens
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leukocyte
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Homo sapiens
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lung epithelium Homo sapiens
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sputum commercial preparation Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information leukocyte elastase induces binding activity of NF-kappaB to lung epithelial cells, and induces phosphorylation of p53 on Ser46 and alters its localization. And leukocyte elastase induces expression of PUMA, a p53-upregulated modulator of apoptosis Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
leukocyte elastase
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Homo sapiens

General Information

General Information Comment Organism
malfunction leukocyte elastase induces apoptosis in lung epithelial cells mediated by a PAR-1-triggered pathway involving activation of NF-kappaB and p53, and a PUMA- and Bax-dependent increase in mitochondrial permeability leading to activation of distal caspases, regulation mechanism, detailed overview Homo sapiens