Literature summary for 3.4.21.37 extracted from

Ekenaes, C.; Zebrowska, A.; Schuler, B.; Vrede, T.; Andreasen, K.; Backlund, A.; Merfort, I.; Bohlin, L.
Screening for anti-inflammatory activity of 12 Arnica (Asteraceae) species assessed by inhibition of NF-kappaB and release of human neutrophil elastase (2008), Planta Med., 74, 1789-1794.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	platelet activating factor and N-formyl-L-methionyl-L-leucyl-L-phenylalanine induce release of neutrophil elastase from neutrophils	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	extracts from 12 Arnica species show inhibition of 10-97% for platelet-activating factor-induced neutrophil elastase release and 1-100% for N-formyl-L-methionyl-L-leucyl-L-phenylalanine-induced neutrophil elastase release from neutrophils	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neutrophil	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
neutrophil elastase	-	Homo sapiens

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Release 2023.1 (January 2023)