Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.37 extracted from

  • Dell'Aica, I.; Sartor, L.; Galletti, P.; Giacomini, D.; Quintavalla, A.; Calabrese, F.; Giacometti, C.; Brunetta, E.; Piazza, F.; Agostini, C.; Garbisa, S.
    Inhibition of leukocyte elastase, polymorphonuclear chemoinvasion, and inflammation-triggered pulmonary fibrosis by a 4-alkyliden-beta-lactam with a galloyl moiety (2006), J. Pharmacol. Exp. Ther., 316, 539-546.
    View publication on PubMed
Search for more literature for 3.4.21.37

Inhibitors

Inhibitors Comment Organism Structure
N-galloyl-4-alkyliden-beta-lactam a beta-lactam with an N-linked galloyl moiety, specific noncompetitive inhibition of the enzyme, but not affecting chemotactic response and viability of polymorphonuclear leukocytes, synthesis and structure, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation from polymorphonuclear leukocytes Homo sapiens
-
polymorphonuclear leukocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
 Homo sapiens N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
leukocyte elastase
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0007
-
 N-galloyl-4-alkyliden-beta-lactam
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.001 0.002
-
 Homo sapiens N-galloyl-4-alkyliden-beta-lactam