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Literature summary for 3.4.21.37 extracted from

  • Young, R.E.; Voisin, M.B.; Wang, S.; Dangerfield, J.; Nourshargh, S.
    Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice (2007), Br. J. Pharmacol., 151, 628-637.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.37

Activating Compound

Activating Compound Comment Organism Structure
additional information potent ability of leukotriene B4 to induce cell-surface expression of neutrophil elastase Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information enzyme-deficient mice do not show inhibition of leukocyte transmigration through leukotriene B4-stimulated cremasteric venules after application of inhibitor ONO-5046, enzyme-deficient mice appear to exhibit compensatory mechanisms in regulation of leukocyte transmigration Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
ONO-5046 a specific inhibitor Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface of neutrophils Mus musculus 9986
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus involvement of neutrophil elastase in leukotriene B4-induced neutrophil transmigration in vivo, specific NE inhibitor suppresses neutrophil migration through IL-1beta-stimulated cremasteric venules at the level of the basement membrane ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 male C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow
-
 Mus musculus
-
commercial preparation
-
 Mus musculus
-
neutrophil from bone marrow Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information involvement of neutrophil elastase in leukotriene B4-induced neutrophil transmigration in vivo, specific NE inhibitor suppresses neutrophil migration through IL-1beta-stimulated cremasteric venules at the level of the basement membrane Mus musculus ?
-
 ?
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O a fluorogenic enzyme-specific substrate Mus musculus N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
neutrophil elastase
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
 assay at Mus musculus