Literature summary for 3.4.21.37 extracted from

Roghanian, A.; Drost, E.M.; MacNee, W.; Howie, S.E.; Sallenave, J.M.
Inflammatory lung secretions inhibit dendritic cell maturation and function via neutrophil elastase (2006), Am. J. Respir. Crit. Care Med., 174, 1189-1198.

Search for more literature for 3.4.21.37

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	release from neutrophils, e.g. in the lung	Homo sapiens	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	inflammatory lung secretions inhibit dendritic cell maturation and function via neutrophil elastase, neutrophil elastase downregulated the expression of CD40, CD80, and CD86, but of not major histocompatibility complex II, on dendritic cells and inhibited LPS-induced dendritic cell maturation, and the the antigen-presenting ability of muring dendritic cells, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	healthy individuals and patients with chronic obstructive pulmonary disease	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neutrophil	synthesis and subsequent release	Homo sapiens	-
sputum	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	inflammatory lung secretions inhibit dendritic cell maturation and function via neutrophil elastase, neutrophil elastase downregulated the expression of CD40, CD80, and CD86, but of not major histocompatibility complex II, on dendritic cells and inhibited LPS-induced dendritic cell maturation, and the the antigen-presenting ability of muring dendritic cells, overview	Homo sapiens	?	-	?
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O	-	Homo sapiens	N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline	-	?

Synonyms

Synonyms	Comment	Organism
neutrophil elastase	-	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	assay at	Homo sapiens

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Release 2023.1 (January 2023)