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Literature summary for 3.4.21.37 extracted from

  • Rees, D.D.; Brain, J.D.; Wohl, M.E.; Humes, J.L.; Mumford, R.A.
    Inhibition of neutrophil elastase in CF sputum by L-658,758 (1997), J. Pharmacol. Exp. Ther., 283, 1201-1206.
    View publication on PubMed
Search for more literature for 3.4.21.37

Inhibitors

Inhibitors Comment Organism Structure
3-acetoxymethyl-7-[S]-methoxy-8-oxo-5-thia-1-aza-6[R]-bicyclo[4.2.0]oct-2-ene-2-(2-(S)-carboxypyrrolidine-carboxamide)-5,5-dioxide L-658,758, cephalosporin-based anti-elastase Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha1-PI + H2O Homo sapiens important antiprotease of the lung, enzyme reduces the lungs’ primary protection against proteolysis ?
-
 ?
Elastin + H2O Homo sapiens involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged ? protein cleaved at at least one location ?
SLPI + H2O Homo sapiens important antiprotease of the lung, enzyme reduces the lungs’ primary protection against proteolysis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 patients with cystic fibrosis
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Homo sapiens
-
sputum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha1-PI + H2O important antiprotease of the lung, enzyme reduces the lungs’ primary protection against proteolysis Homo sapiens ?
-
 ?
Elastin + H2O
-
 Homo sapiens ?
-
 ?
Elastin + H2O involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged Homo sapiens ? protein cleaved at at least one location ?
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
 Homo sapiens methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
 ?
Protein + H2O enzyme capable of degrading proteins of the lung extracellular matrix in vitro Homo sapiens ?
-
 ?
SLPI + H2O important antiprotease of the lung, enzyme reduces the lungs’ primary protection against proteolysis Homo sapiens ?
-
 ?