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Literature summary for 3.4.21.37 extracted from
- Inhibition of PMN-elastase activity by semisynthetic glucan sulfates (2003), Thromb. Haemost., 89, 915-925.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cephalotin | IC50: 0.00025 mg/ml | Homo sapiens |  |
| semisynthetic glucan sulfates | with pullulan as basic polysaccharide: PulS1, PulS2, PulS3 (IC50: 0.0000181 mM), PulS4, PulS5, PulS6 and PulS7, with glucuronoxylan as basic polysaccharide: PPS, and with phycarine as basic polysaccharide: PS3 | Homo sapiens | |
| ursolic acid | IC50: 0.0337 | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | proteolysis of connective tissue by enzymes such as PMN-elastase is a crucial step during inflammation and metastasis | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | proteolysis of connective tissue by enzymes such as PMN-elastase is a crucial step during inflammation and metastasis | Homo sapiens | ? | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000008 | - |
semisynthetic glucan sulfate PulS7 | 37°C | Homo sapiens | |
| 0.000001 | - |
semisynthetic glucan sulfate PulS6 | 37°C | Homo sapiens | |
| 0.0000034 | - |
semisynthetic glucan sulfate PulS5 | 37°C | Homo sapiens | |
| 0.0000056 | - |
semisynthetic glucan sulfate UFH | 37°C | Homo sapiens | |
| 0.000012 | - |
semisynthetic glucan sulfate PulS1 | 37°C | Homo sapiens | |
| 0.0000132 | - |
semisynthetic glucan sulfate PS3 | 37°C | Homo sapiens | |
| 0.0000185 | - |
semisynthetic glucan sulfate PPS | 37°C | Homo sapiens | |
| 0.0000215 | - |
semisynthetic glucan sulfate PulS2 | 37°C | Homo sapiens | |
| 0.000036 | - |
semisynthetic glucan sulfate PulS3 | 37°C | Homo sapiens | |
| 0.000044 | - |
semisynthetic glucan sulfate PulS4 | 37°C | Homo sapiens | |
| 0.000058 | - |
semisynthetic glucan sulfate LMWH | 37°C | Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0000181 | - |
with pullulan as basic polysaccharide: PulS1, PulS2, PulS3 (IC50: 0.0000181 mM), PulS4, PulS5, PulS6 and PulS7, with glucuronoxylan as basic polysaccharide: PPS, and with phycarine as basic polysaccharide: PS3 | Homo sapiens | semisynthetic glucan sulfates | |
| 0.0337 | - |
IC50: 0.0337 mM | Homo sapiens | ursolic acid | |
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