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Literature summary for 3.4.21.37 extracted from

  • Pacholok, S.G.; Davies, P.; Dorn, C.; Finke, P.; Hanlon, W.A.; Mumford, R.A.; Humes, J.L.
    Formation of polymorphonuclear leukocyte elastase:alpha1 proteinase inhibitor complex and Aalpha(1-21) fibrinopeptide in human blood stimulated with the calcium ionophore A23187. A model to characterize inhibitors of polymorphonuclear leukocyte elastase (1995), Biochem. Pharmacol., 49, 1513-1520.
    View publication on PubMed
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Application

Application Comment Organism
medicine the synthetic inhibitor 2,3-dihydro-6-[3-(2-hydroxymethyl)-phenyl-2-propenyl]5-benzofuranol may provide a new and useful therapeutic for the treatment of diseases characterized by polymorphonuclear elastase involvement Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2,3-dihydro-6-[3-(2-hydroxymethyl)-phenyl-2-propenyl]5-benzofuranol the synthetic inhibitor may provide a new and useful therapeutic for the treatment of diseases characterized by polymorphonuclear elastase involvement Homo sapiens
4-((1-(((1-(R)-(5-benzofuranyl)butyl)amino)carbonyl)-3,3-diethyl-4-oxo-2-(S)-azetidinyl)oxy)benzene acetic acid the synthetic inhibitor may provide a new and useful therapeutic for the treatment of diseases characterized by polymorphonuclear elastase involvement Homo sapiens
Alpha1-proteinase inhibitor
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme may contribute to the intracellular degradation of phagocytized material, its release from activated polymorphonuclear leukocytes into extracellular spaces. The enzyme has been implicated in the pathogenesis of various diseases and is thought to be responsible for tissue damage ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte polymorphonuclear leukocytes Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme may contribute to the intracellular degradation of phagocytized material, its release from activated polymorphonuclear leukocytes into extracellular spaces. The enzyme has been implicated in the pathogenesis of various diseases and is thought to be responsible for tissue damage Homo sapiens ?
-
 ?