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Literature summary for 3.4.21.36 extracted from

  • Stergiou, P.Y.; Foukis, A.; Gkini, O.A.; Bieth, J.G.; Papamichael, E.M.
    Kinetic and computational analysis of the reversible inhibition of porcine pancreatic elastase a structural and mechanistic approach (2016), J. Enzyme Inhib. Med. Chem., 31, 131-139 .
    View publication on PubMed
Search for more literature for 3.4.21.36

Inhibitors

Inhibitors Comment Organism Structure
N-(trifluoroacetyl)-alpha-aspartyl-N-[4-(trifluoromethyl)phenyl]alaninamide reversible inhibitor Sus scrofa
N-(trifluoroacetyl)leucyl-N-[4-(trifluoromethyl)phenyl]alaninamide reversible inhibitor Sus scrofa
N-(trifluoroacetyl)valyl-N-[4-(trifluoromethyl)phenyl]alaninamide reversible inhibitor Sus scrofa
N2-(trifluoroacetyl)lysyl-N-[4-(trifluoromethyl)phenyl]alaninamide reversible inhibitor Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.504
-
 succinyl-L-Ala-L-Ala-L-Ala-4-nitroanilide at pH 8.0 and 25°C Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreas
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinyl-L-Ala-L-Ala-L-Ala-4-nitroanilide + H2O
-
 Sus scrofa succinyl-L-Ala-L-Ala-L-Ala + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
pancreatic elastase
-
 Sus scrofa
PPE
-
 Sus scrofa

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.039
-
 succinyl-L-Ala-L-Ala-L-Ala-4-nitroanilide at pH 8.0 and 25°C Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000236
-
 N-(trifluoroacetyl)leucyl-N-[4-(trifluoromethyl)phenyl]alaninamide at pH 8.0 and 25°C Sus scrofa

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.06
-
 succinyl-L-Ala-L-Ala-L-Ala-4-nitroanilide at pH 8.0 and 25°C Sus scrofa