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Literature summary for 3.4.21.34 extracted from

  • Feener, E.P.; Zhou, Q.; Fickweiler, W.
    Role of plasma kallikrein in diabetes and metabolism (2013), Thromb. Haemost., 110, 434-441.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.34

Activating Compound

Activating Compound Comment Organism Structure
coagulation factor XIIa
-
 Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
alpha 2 macroglobulin
-
 Mus musculus
C1-inhibitor
-
 Mus musculus
Protein C inhibitor
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor X + H2O Mus musculus
-
 factor XIIa + ?
-
 ?
high molecular weight kininogen + H2O Mus musculus
-
 bradykinin + fragments of kininogen
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Mus musculus
-
vascular endothelium
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor X + H2O
-
 Mus musculus factor XIIa + ?
-
 ?
high molecular weight kininogen + H2O
-
 Mus musculus bradykinin + fragments of kininogen
-
 ?

Synonyms

Synonyms Comment Organism
KLKb1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction C1-inhibitor deficiency can lead to uncontrolled enzyme activity, which is a clinically significant cause of hereditary angioedema Mus musculus
physiological function diabetes is associated with increased intrinsic pathway activity, which is mediated in part by plasma kallikrein (PK). PK-mediated activation of the plasminogen cascade is implicated in adipocyte differentiation and adipogenesis during mammary gland involution via activation of plasmin-mediated cleavage of preadipocyte stromal matrix Mus musculus