Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.34 extracted from

  • Pathak, M.; Wong, S.S.; Dreveny, I.; Emsley, J.
    Structure of plasma and tissue kallikreins (2013), Thromb. Haemost., 110, 423-433.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
coagulation factor XIIa
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor FXII + H2O Homo sapiens cleavage between Arg and Val activated factor XII + ?
-
?
high-molecular-weight kininogen + H2O Homo sapiens cleavage between Lys and Arg as wekk as Arg and Ser bradykinin + fragments of kininogen
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P03952
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor FXII + H2O cleavage between Arg and Val Homo sapiens activated factor XII + ?
-
?
high-molecular-weight kininogen + H2O cleavage between Lys and Arg as wekk as Arg and Ser Homo sapiens bradykinin + fragments of kininogen
-
?
additional information peptides with Pro at P2 are poor substrates Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
KLKb1
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the activated form of PK is involved in blood pressure regulation Homo sapiens