Activating Compound | Comment | Organism | Structure |
---|---|---|---|
factor XIIa | - |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Aprotinin | - |
Homo sapiens | |
C1INH | - |
Homo sapiens | |
ecallantide | DX-88 | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
79500 | - |
x * 79500, prekallikrein, calculated from amino acid sequence | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor B + H2O | Homo sapiens | - |
factor Bb + ? | - |
? | |
factor XII + H2O | Homo sapiens | - |
factor XIIa + ? | - |
? | |
high-molecular-weight kininogen + H2O | Homo sapiens | - |
bradykinin + fragments of kininogen | - |
? | |
pro-urokinase type plasminogen activator + H2O | Homo sapiens | - |
urokinase type plasminogen activator + ? | - |
? | |
Prorenin + H2O | Homo sapiens | - |
Renin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor B + H2O | - |
Homo sapiens | factor Bb + ? | - |
? | |
factor XII + H2O | - |
Homo sapiens | factor XIIa + ? | - |
? | |
high-molecular-weight kininogen + H2O | - |
Homo sapiens | bradykinin + fragments of kininogen | - |
? | |
pro-urokinase type plasminogen activator + H2O | - |
Homo sapiens | urokinase type plasminogen activator + ? | - |
? | |
Prorenin + H2O | - |
Homo sapiens | Renin + ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 79500, prekallikrein, calculated from amino acid sequence | Homo sapiens |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Homo sapiens | calculated from amino acid sequence | - |
8.59 |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme drives multiple proteolytic reaction cascades in the cardiovascular system such as the intrinsic pathway of coagulation, the kallikrein-kinin system, the fibrinolytic system, the renin-angiotensin system and the alternative complement pathway | Homo sapiens |