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Literature summary for 3.4.21.34 extracted from

  • Renne, T.; Gruber, A.
    Plasma kallikrein: Novel functions for an old protease (2012), Thromb. Haemost., 107, 1012-1013.
    View publication on PubMed
Search for more literature for 3.4.21.34

Activating Compound

Activating Compound Comment Organism Structure
factor XIIa
-
 Mus musculus

Application

Application Comment Organism
medicine targeting plasma kallikrein may offer a strategy for prevention or treatment of thrombosis Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
high-molecular-weight kininogen + H2O Mus musculus
-
 bradykinin + fragments of kininogen
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Mus musculus
-
liver the enzyme is expressed in liver Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
high-molecular-weight kininogen + H2O
-
 Mus musculus bradykinin + fragments of kininogen
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 86000-88000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
plasma prokallikrein zymogen Mus musculus

General Information

General Information Comment Organism
malfunction enzyme deficiency has minor effect on the haemostatic capacity of gene-deficient mice Mus musculus
physiological function the enzyme drives procoagulant and proinflammatory reactions via the intrinsic pathway of coagulation and the kallikrein-kinin system, respectively Mus musculus