Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.34 extracted from

  • Liu, J.; Gao, B.B.; Clermont, A.C.; Blair, P.; Chilcote, T.J.; Sinha, S.; Flaumenhaft, R.; Feener, E.P.
    Hyperglycemia-induced cerebral hematoma expansion is mediated by plasma kallikrein (2011), Nat. Med., 17, 206-210.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.34

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
kininogen + H2O Rattus norvegicus
-
 bradykinin + fragments of kininogen
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
kininogen + H2O
-
 Rattus norvegicus bradykinin + fragments of kininogen
-
 ?

General Information

General Information Comment Organism
malfunction cerebral hematoma expansion triggered by intracerebral infusion of autologous blood is increased in diabetic rats, and this response is ameliorated by plasma kallikrein inhibition and deficiency, respectively Rattus norvegicus
physiological function hyperglycemia increases cerebral hematoma expansion by plasma kallikrein-mediated osmotic sensitive inhibition of hemostasis, plasma kallikrein-mediated inhibition of collagen-induced platelet aggregation is enhanced by hyperglycemia Rattus norvegicus