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Literature summary for 3.4.21.34 extracted from

  • Abdallah, R.T.; Keum, J.S.; El-Shewy, H.M.; Lee, M.H.; Wang, B.; Gooz, M.; Luttrell, D.K.; Luttrell, L.M.; Jaffa, A.A.
    Plasma kallikrein promotes epidermal growth factor receptor transactivation and signaling in vascular smooth muscle through direct activation of protease-activated receptors (2010), J. Biol. Chem., 285, 35206-35215.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.34

Inhibitors

Inhibitors Comment Organism Structure
Aprotinin
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Pro-Phe-Arg-4-nitroanilide + H2O
-
 Homo sapiens D-Pro-Phe-Arg + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
plasma KK
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function plasma kallikrein directly activates G protein-coupled protease-activated receptors (PAR) 1 and 2. Plasma kallikrein stimulates ADAM (a disintegrin and metalloprotease) 17 activity via a PAR1/2 receptor-dependent mechanism, leading sequentially to release of the endogenous ADAM17 substrates, amphiregulin and tumor necrosis factor-alpha, metalloprotease-dependent transactivation of epidermal growth factor receptors, and metalloprotease and epidermal growth factor receptor-dependent ERK1/2 activation Homo sapiens