Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ecotin | ecotin with mutation H53P in the 50s loop, mutations S82W/T83N/M84R/M85R/A86S in the 80s loop and mutations R108S/N110S in the 100s loop is a high-affinity and highly specific plasma kallikrein inhibitor. Specifically inhibits contact activation of human plasma at the level mediated by plasma kallikrein. Discriminates between enzyme and zymogen. Partial thromboplastin time inhibition can be rescued by addition of PKal | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Pro-Phe-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKal | - |
Homo sapiens |
plasma kallikrein | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000000011 | - |
ecotin | ecotin with mutation H53P in the 50s loop, mutations S82W/T83N/M84R/M85R/A86S in the 80s loop and mutations R108S/N110S in the 100s loop, at room temperature | Homo sapiens | |
0.000000014 | - |
ecotin | ecotin with mutation H53P in the 50s loop and mutations S82W/T83N/M84R/M85R/A86S in the 80s loop, at room temperature | Homo sapiens | |
0.000000025 | - |
ecotin | ecotin with mutations S82W/T83N/M84R/M85R/A86S in the 80s loop and mutations R108S/N110S in the 100s loop, at room temperature | Homo sapiens | |
0.000000037 | - |
ecotin | ecotin with mutations S82W/T83N/M84R/M85R/A86S in the 80s loop, at room temperature | Homo sapiens | |
0.000000066 | - |
ecotin | wild-type ecotin, at room temperature | Homo sapiens | |
0.000000097 | - |
ecotin | ecotin with mutation H53P in the 50s loop, at room temperature | Homo sapiens | |
0.000000118 | - |
ecotin | ecotin with mutations R108S/N110S in the 100s loop, at room temperature | Homo sapiens | |
0.000000186 | - |
ecotin | ecotin with mutation H53P in the 50s loop and mutations R108S/N110S in the 100s loop, at room temperature | Homo sapiens |