Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.34 extracted from

  • Isawa, H.; Orito, Y.; Jingushi, N.; Iwanaga, S.; Morita, A.; Chinzei, Y.; Yuda, M.
    Identification and characterization of plasma kallikrein-kinin system inhibitors from salivary glands of the blood-sucking insect Triatoma infestans (2007), FEBS J., 274, 4271-4286.
    View publication on PubMed
Search for more literature for 3.4.21.34

Inhibitors

Inhibitors Comment Organism Structure
triafestin-1 isolation and analysis of the enzyme inhibitor from salivary glands of instar nymphs of Triatoma infestans, SwissProt ID A7BJ45, recombinant production in insect or Escherichia coli cells, triafestin-1 specifically interacts with factor XII and high molecular weight kininogen in a Zn2+-dependent manner, and inhibit activation of the kallikrein-kinin system by interfering with the association of factor XII and high molecular weight kininogen with biological activating surfaces as well as inhibiting prekallikrein activation, overview Homo sapiens
triafestin-2 isolation and analysis of enzyme inhibitors from salivary glands of instar nymphs of Triatoma infestans, SwissProt ID A7BJ46, recombinant production in insect or Escherichia coli cells, triafestin-2 specifically interacts with factor XII and high molecular weight kininogen in a Zn2+-dependent manner, and inhibit activation of the kallikrein-kinin system by interfering with the association of factor XII and high molecular weight kininogen with biological activating surfaces as well as inhibiting prekallikrein activation, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor XI + H2O Homo sapiens proteolytic activation activated factor XI + ?
-
 ?
factor XII + H2O Homo sapiens proteolytic activation activated factor XII + ?
-
 ?
high-molecular-weight kininogen + H2O Homo sapiens
-
 high-molecular-weight kinin + bradykinin bradykinin is Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg ?
low-molecular-weight kininogen + H2O Homo sapiens
-
 low-molecular-weight kinin + kallidin kallidin is Lys-bradykinin or Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg ?
additional information Homo sapiens the enzyme is part of the kallikrein-kininogen-kinin system, KKS, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor XI + H2O proteolytic activation Homo sapiens activated factor XI + ?
-
 ?
factor XII + H2O proteolytic activation Homo sapiens activated factor XII + ?
-
 ?
high-molecular-weight kininogen + H2O
-
 Homo sapiens high-molecular-weight kinin + bradykinin bradykinin is Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg ?
low-molecular-weight kininogen + H2O
-
 Homo sapiens low-molecular-weight kinin + kallidin kallidin is Lys-bradykinin or Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg ?
additional information the enzyme is part of the kallikrein-kininogen-kinin system, KKS, overview Homo sapiens ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens