Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | kallikrein | Homo sapiens | - |
- |
intracellular | prekallikrein | Homo sapiens | 5622 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | kallikrein participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation, it has different specific cellular functions dependent on the tissue, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P03952 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | prekallikrein is synthesized in hepatocytes and other cell types and secreted to the blood, and proteolytically activated to kallikrein | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast | synthesis of prekallikrein | Homo sapiens | - |
kidney | single cells of the distal tubules, synthesis of prekallikrein | Homo sapiens | - |
Langerhans cell | synthesis of prekallikrein | Homo sapiens | - |
Leydig cell | synthesis of prekallikrein | Homo sapiens | - |
liver | plasma prekallikrein is synthesised in hepatocytes and epithalial liver cells, and secreted into the blood | Homo sapiens | - |
oesophagus | synthesis of prekallikrein | Homo sapiens | - |
ovary | follicular and thecal granulosa cells | Homo sapiens | - |
parotid gland | synthesis of prekallikrein | Homo sapiens | - |
plasma | kallikrein | Homo sapiens | - |
prostate | synthesis of prekallikrein | Homo sapiens | - |
respiratory tract | synthesis of prekallikrein | Homo sapiens | - |
skin | synthesis of prekallikrein | Homo sapiens | - |
testis | interstitial Leydig cells of the testes, synthesis of prekallikrein | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | kallikrein participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation, it has different specific cellular functions dependent on the tissue, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PPK | - |
Homo sapiens |