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Literature summary for 3.4.21.34 extracted from

  • Rojkjaer, R.; Schmaier, A.H.
    Activation of the plasma kallikrein/kinin system on endothelial cell membranes (1999), Immunopharmacology, 43, 109-114.
    View publication on PubMed
Search for more literature for 3.4.21.34

Activating Compound

Activating Compound Comment Organism Structure
Factor XII essential for activation on artificial surfaces Homo sapiens
kininogen dependent on in vivo, high molecular weight, in complex with prekallikrein Homo sapiens
additional information prekallikrein activation mechanism, in vitro activated when expose to artificial negatively charged surfaces, in vivo activated as prekallikrein/kininogen complex by an antipain sensitive protease Homo sapiens
Zn2+ prekallikrein, required, optimal activation on cells at 0.008 mM, activation range 0.005-0.01 mM, higher concentration inhibit, regulatory role Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-mercaptoethanol inhibition of prekallikrein activation Homo sapiens
antipain inhibition of prekallikrein activation Homo sapiens
cysteine inhibition of prekallikrein activation Homo sapiens
dithiothreitol inhibition of prekallikrein activation Homo sapiens
glutathione inhibition of prekallikrein activation Homo sapiens
HgCl2 inhibition of prekallikrein activation Homo sapiens
Z-Phe-OH inhibition of prekallikrein activation Homo sapiens
Zn2+ inhibits the activation of prekallikrein at concentrations above 0.01 mM, regulatory role Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane complexed with kininogen Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
kininogen + H2O Homo sapiens
-
 bradykinin + fragment of kininogen
-
 ir
additional information Homo sapiens involved in plasma and vascular fibrinolytic activity ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell surface, prekallikrein Homo sapiens
-
plasma
-
 Homo sapiens
-
platelet surface Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor XII + H2O activation of factor XII Homo sapiens ?
-
 ?
kininogen + H2O
-
 Homo sapiens bradykinin + fragment of kininogen
-
 ?
kininogen + H2O
-
 Homo sapiens bradykinin + fragment of kininogen
-
 ir
additional information involved in plasma and vascular fibrinolytic activity Homo sapiens ?
-
 ?
plasminogen + H2O activation of plasminogen Homo sapiens plasmin + ?
-
 ir
pro-urokinase + H2O activation of pro-urokinase Homo sapiens urokinase + ?
-
 ?