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Literature summary for 3.4.21.34 extracted from

  • Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
    The SWISS-PROT protein knowledgebase and its supplement TrEMBL (2003), Nucleic Acids Res., 31, 365-370.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
factor XIIa activation by cleavage into light- and heavy-chain, that are linked by one or more disulfide bridges after cleavage Homo sapiens
factor XIIa activation by cleavage into light- and heavy-chain, that are linked by one or more disulfide bridges after cleavage Rattus norvegicus
factor XIIa activation by cleavage into light- and heavy-chain, that are linked by one or more disulfide bridges after cleavage Mus musculus
additional information binding to negatively charged surfaces activates the enzyme Homo sapiens
additional information binding to negatively charged surfaces activates the enzyme Rattus norvegicus
additional information binding to negatively charged surfaces activates the enzyme Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble plasma Homo sapiens
-
-
soluble plasma Rattus norvegicus
-
-
soluble plasma Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor XII + H2O Homo sapiens activation of the factor XII, bound to negatively charged surfaces ?
-
ir
factor XII + H2O Rattus norvegicus activation of the factor XII, bound to negatively charged surfaces ?
-
ir
factor XII + H2O Mus musculus activation of the factor XII, bound to negatively charged surfaces ?
-
ir
kininogen + H2O Homo sapiens high-molecular weight kininogen bradykinin + fragments of kininogen
-
ir
kininogen + H2O Rattus norvegicus high-molecular weight kininogen bradykinin + fragments of kininogen
-
ir
kininogen + H2O Mus musculus high-molecular weight kininogen bradykinin + fragments of kininogen
-
ir
additional information Homo sapiens defects in gene KLKB1 cause Fletcher factor deficiency, a blood coagulation defect ?
-
?
Prorenin + H2O Homo sapiens activation of prorenin, involved in the renin-angiotensin system Renin + ?
-
ir
Prorenin + H2O Rattus norvegicus activation of prorenin, involved in the renin-angiotensin system Renin + ?
-
ir
Prorenin + H2O Mus musculus activation of prorenin, involved in the renin-angiotensin system Renin + ?
-
ir

Organism

Organism UniProt Comment Textmining
Homo sapiens P03952 gene KLK3 or KLKB1, plasma kallikrein precursor
-
Mus musculus P26262 gene KLKB1 or KLK3 or PK, plasma kallikrein precursor
-
Rattus norvegicus P14272 gene KLKB1 or PK, plasma kallikrein precursor
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
Homo sapiens
-
plasma
-
Rattus norvegicus
-
plasma
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor XII + H2O activation of the factor XII, bound to negatively charged surfaces Homo sapiens ?
-
?
factor XII + H2O activation of the factor XII, bound to negatively charged surfaces Homo sapiens ?
-
ir
factor XII + H2O activation of the factor XII, bound to negatively charged surfaces Rattus norvegicus ?
-
?
factor XII + H2O activation of the factor XII, bound to negatively charged surfaces Rattus norvegicus ?
-
ir
factor XII + H2O activation of the factor XII, bound to negatively charged surfaces Mus musculus ?
-
?
factor XII + H2O activation of the factor XII, bound to negatively charged surfaces Mus musculus ?
-
ir
kininogen + H2O high-molecular weight kininogen Homo sapiens bradykinin + fragments of kininogen
-
?
kininogen + H2O high-molecular weight kininogen Homo sapiens bradykinin + fragments of kininogen
-
ir
kininogen + H2O high-molecular weight kininogen Rattus norvegicus bradykinin + fragments of kininogen
-
?
kininogen + H2O high-molecular weight kininogen Rattus norvegicus bradykinin + fragments of kininogen
-
ir
kininogen + H2O high-molecular weight kininogen Mus musculus bradykinin + fragments of kininogen
-
ir
kininogen + H2O human high-molecular weight kininogen Mus musculus bradykinin + fragments of kininogen
-
?
additional information belongs to the peptidase family S1, plasma kallikrein subfamily Homo sapiens ?
-
?
additional information belongs to the peptidase family S1, plasma kallikrein subfamily Rattus norvegicus ?
-
?
additional information belongs to the peptidase family S1, plasma kallikrein subfamily Mus musculus ?
-
?
additional information defects in gene KLKB1 cause Fletcher factor deficiency, a blood coagulation defect Homo sapiens ?
-
?
Prorenin + H2O activation of prorenin Homo sapiens Renin + ?
-
ir
Prorenin + H2O activation of prorenin Rattus norvegicus Renin + ?
-
ir
Prorenin + H2O activation of prorenin Mus musculus Renin + ?
-
ir
Prorenin + H2O activation of prorenin, involved in the renin-angiotensin system Homo sapiens Renin + ?
-
ir
Prorenin + H2O activation of prorenin, involved in the renin-angiotensin system Rattus norvegicus Renin + ?
-
ir
Prorenin + H2O activation of prorenin, involved in the renin-angiotensin system Mus musculus Renin + ?
-
ir