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Literature summary for 3.4.21.27 extracted from

  • Fradera, X.; Kazemier, B.; Carswell, E.; Cooke, A.; Oubrie, A.; Hamilton, W.; Dempster, M.; Krapp, S.; Nagel, S.; Jestel, A.
    High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors (2012), Acta Crystallogr. Sect. F, 68, 404-408.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Pichia pastoris Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with inhibitors, hanging drop vapor diffusion method, using 0.1 M citrate pH 4.7-5.2, 20-26% (w/v) PEG 4K Homo sapiens

Protein Variants

Protein Variants Comment Organism
C500S inactive Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N-[(2S)-1-([2-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]ethyl]amino)-1-oxo-3-phenylpropan-2-yl]-3-oxo-3,4-dihydro-2H-1,4-benzothiazine-7-carboxamide
-
Homo sapiens
[4-[(N-[3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]propanoyl]-L-phenylalanyl)amino]phenyl]acetic acid
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor IX + H2O Homo sapiens
-
factor IXa + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P03951
-
-

Purification (Commentary)

Purification (Comment) Organism
Zn2+-chelating Sepharose column chromatography and SP Sepharose column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor IX + H2O
-
Homo sapiens factor IXa + ?
-
?

Synonyms

Synonyms Comment Organism
coagulation factor XI
-
Homo sapiens
FXIa
-
Homo sapiens