Activating Compound | Comment | Organism | Structure |
---|---|---|---|
factor XIIa | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | factor XIa activates factor IX upon the addition of Ca2+ | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
80000 | - |
2 * 80000 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor IX + H2O | Homo sapiens | - |
activated factor IX + ? | - |
? | |
factor V + H2O | Homo sapiens | fXIa cleaves COOH-terminal to R306, possibly at the fXa/plasmin cleavage site R348 | activated factor V + ? | - |
? | |
factor VIII + H2O | Homo sapiens | fXIa initially cleaves at R740 and R372 in the heavy chain and also makes several A3 cleavages most notably at R1652 and R1721 | activated factor VIII + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor IX + H2O | - |
Homo sapiens | activated factor IX + ? | - |
? | |
factor V + H2O | fXIa cleaves COOH-terminal to R306, possibly at the fXa/plasmin cleavage site R348 | Homo sapiens | activated factor V + ? | - |
? | |
factor VIII + H2O | fXIa initially cleaves at R740 and R372 in the heavy chain and also makes several A3 cleavages most notably at R1652 and R1721 | Homo sapiens | activated factor VIII + ? | - |
? | |
SN-13a + H2O | specific substrate for factor XIa | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 80000 | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
factor XIa | - |
Homo sapiens |
FXIa | - |
Homo sapiens |