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Literature summary for 3.4.21.27 extracted from

  • Whelihan, M.F.; Orfeo, T.; Gissel, M.T.; Mann, K.G.
    Coagulation procofactor activation by factor XIa (2010), J. Thromb. Haemost., 8, 1532-1539.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
factor XIIa
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ factor XIa activates factor IX upon the addition of Ca2+ Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
2 * 80000 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor IX + H2O Homo sapiens
-
activated factor IX + ?
-
?
factor V + H2O Homo sapiens fXIa cleaves COOH-terminal to R306, possibly at the fXa/plasmin cleavage site R348 activated factor V + ?
-
?
factor VIII + H2O Homo sapiens fXIa initially cleaves at R740 and R372 in the heavy chain and also makes several A3 cleavages most notably at R1652 and R1721 activated factor VIII + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor IX + H2O
-
Homo sapiens activated factor IX + ?
-
?
factor V + H2O fXIa cleaves COOH-terminal to R306, possibly at the fXa/plasmin cleavage site R348 Homo sapiens activated factor V + ?
-
?
factor VIII + H2O fXIa initially cleaves at R740 and R372 in the heavy chain and also makes several A3 cleavages most notably at R1652 and R1721 Homo sapiens activated factor VIII + ?
-
?
SN-13a + H2O specific substrate for factor XIa Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
homodimer 2 * 80000 Homo sapiens

Synonyms

Synonyms Comment Organism
factor XIa
-
Homo sapiens
FXIa
-
Homo sapiens