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Literature summary for 3.4.21.27 extracted from

  • Navaneetham, D.; Sinha, D.; Walsh, P.N.
    Mechanisms and specificity of factor XIa and trypsin inhibition by protease nexin 2 and basic pancreatic trypsin inhibitor (2010), J. Biochem., 148, 467-479.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.27

Inhibitors

Inhibitors Comment Organism Structure
basic pancreatic trypsin inhibitor competitive inhibition Homo sapiens
basic pancreatic trypsin inhibitor mutant K15R
-
 Homo sapiens
additional information not inhibited by protease nexin-2 mutant R15A Homo sapiens
protease nexin-2 highly specific and potent inhibitor of FXIa, is about 775fold more potent than basic pancreatic trypsin inhibitor in FXIa inhibition, provides single-step slow equilibration inhibition Homo sapiens
protease nexin-2 mutant F34A
-
 Homo sapiens
protease nexin-2 mutant M17A
-
 Homo sapiens
protease nexin-2 mutant P13A
-
 Homo sapiens
protease nexin-2 mutant R15K
-
 Homo sapiens
protease nexin-2 mutant R20A
-
 Homo sapiens
protease nexin-2 mutant S19A
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor IX + H2O Homo sapiens
-
 activated factor IX + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P03951
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Boc-Glu(OBzl)-Ala-Arg-4-methylcoumaryl-7-amide + H2O
-
 Homo sapiens Boc-Glu(OBzl)-Ala-Arg + 7-amino-4-methylcoumarin
-
 ?
factor IX + H2O
-
 Homo sapiens activated factor IX + ?
-
 ?
L-pyro-Glu-Pro-Arg-4-nitroanilide + H2O i.e. S-2366 Homo sapiens L-pyro-Glu-Pro-Arg + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
factor XIa
-
 Homo sapiens
FXIa
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000081
-
 protease nexin-2 in 50 mM Tris, 150 mM NaCl, 5 mM CaCl2, 0.1% (w/v) bovine serum albumin, pH 7.5, at 37°C Homo sapiens
0.00000081
-
 protease nexin-2 mutant M17A in 50 mM Tris, 150 mM NaCl, 5 mM CaCl2, 0.1% (w/v) bovine serum albumin, pH 7.5, at 37°C Homo sapiens
0.00000093
-
 protease nexin-2 mutant S19A in 50 mM Tris, 150 mM NaCl, 5 mM CaCl2, 0.1% (w/v) bovine serum albumin, pH 7.5, at 37°C Homo sapiens
0.00000283
-
 protease nexin-2 mutant R20A in 50 mM Tris, 150 mM NaCl, 5 mM CaCl2, 0.1% (w/v) bovine serum albumin, pH 7.5, at 37°C Homo sapiens
0.00000296
-
 protease nexin-2 mutant P13A in 50 mM Tris, 150 mM NaCl, 5 mM CaCl2, 0.1% (w/v) bovine serum albumin, pH 7.5, at 37°C Homo sapiens
0.0000041
-
 basic pancreatic trypsin inhibitor mutant K15R in 50 mM Tris, 150 mM NaCl, 5 mM CaCl2, 0.1% (w/v) bovine serum albumin, pH 7.5, at 37°C Homo sapiens
0.00000492
-
 protease nexin-2 mutant F34A in 50 mM Tris, 150 mM NaCl, 5 mM CaCl2, 0.1% (w/v) bovine serum albumin, pH 7.5, at 37°C Homo sapiens
0.0000113
-
 protease nexin-2 mutant R15K in 50 mM Tris, 150 mM NaCl, 5 mM CaCl2, 0.1% (w/v) bovine serum albumin, pH 7.5, at 37°C Homo sapiens
0.000627
-
 basic pancreatic trypsin inhibitor in 50 mM Tris, 150 mM NaCl, 5 mM CaCl2, 0.1% (w/v) bovine serum albumin, pH 7.5, at 37°C Homo sapiens