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Literature summary for 3.4.21.27 extracted from

  • Jin, L.; Pandey, P.; Babine, R.E.; Gorga, J.C.; Seidl, K.J.; Gelfand, E.; Weaver, D.T.; Abdel-Meguid, S.S.; Strickler, J.E.
    Crystal structures of the FXIa catalytic domain in complex with ecotin mutants reveal substrate-like interactions (2005), J. Biol. Chem., 280, 4704-4712.
    View publication on PubMed
Search for more literature for 3.4.21.27

Activating Compound

Activating Compound Comment Organism Structure
FXIa
-
 Homo sapiens
FXIIa
-
 Homo sapiens
thrombin
-
 Homo sapiens

Application

Application Comment Organism
medicine anti-thrombosis therapy Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Pichia pastoris Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
anti-thrombin III
-
 Homo sapiens
ecotin
-
 Homo sapiens
protease hexin II
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
 2 * 80000, SDS-PAGE Homo sapiens
160000
-
 SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
immobilized Zn2-chelate chromatography and cation exchange chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-pyroglutamyl-L-prolyl-L-arginyl-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens L-pyroglutamyl-L-prolyl-L-arginine + 7-amino-4-methylcoumarin
-
 ?

Subunits

Subunits Comment Organism
homodimer 2 * 80000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
activated coagulation factor XIa
-
 Homo sapiens
coagulation factor XI
-
 Homo sapiens
FXI
-
 Homo sapiens
FXIa
-
 Homo sapiens