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Literature summary for 3.4.21.27 extracted from
- Mechanism-based isocoumarin inhibitors for trypsin and blood coagulation serine proteases: new anticoagulants (1988), Biochemistry, 27, 2547-2557.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-alkoxy-4-chloro-7-guanidinoisocoumarin | - |
Homo sapiens |  |
| 4-chloro-3-isothiureidoalkoxyisocoumarin | - |
Homo sapiens | |
| additional information | - |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor IX + H2O | Homo sapiens | activation of Factor IX in the intrinsic coagulation cascade | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor IX + H2O | activation of Factor IX in the intrinsic coagulation cascade | Homo sapiens | ? | - |
? | |
| factor IX + H2O | - |
Homo sapiens | factor IXa + peptide | - |
? | |
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