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Literature summary for 3.4.21.26 extracted from

  • Nozaki, Y.; Sato, N.; Iida, T.; Hara, K.; Fukuyama, K.; Epstein, W.L.
    Prolyl endopeptidase purified from granulomatous inflammation in mice (1992), J. Cell. Biochem., 49, 296-303.
    View publication on PubMed
Search for more literature for 3.4.21.26

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-Pro-prolinal
-
 Mus musculus
Cu2+
-
 Mus musculus
diisopropylfluorophosphate
-
 Mus musculus
Hg2+
-
 Mus musculus
N-ethylmaleimide
-
 Mus musculus
p-chloromercuribenzoate
-
 Mus musculus
Zn2+
-
 Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.015
-
 benzyloxycarbonyl-Gly-Pro-4-methylcoumarin 7-amide
-
 Mus musculus
0.016
-
 angiotensin I
-
 Mus musculus
0.018
-
 benzyloxycarbonyl-Ala-Pro-2-naphthylamide
-
 Mus musculus
0.029
-
 N-carbobenzoxy-Gly-Pro 2-naphthylamide
-
 Mus musculus
0.036
-
 angiotensin II
-
 Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
78000
-
 1 * 78000, SDS-PAGE Mus musculus
79000
-
 gel filtration Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
liver granulomatous inflammation Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
5.53
-
-
 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
 Mus musculus ?
-
 ?
angiotensin II + H2O
-
 Mus musculus ?
-
 ?
benzyloxycarbonyl-Ala-Pro-2-naphthylamide + H2O
-
 Mus musculus ?
-
 ?
benzyloxycarbonyl-Gly-Pro-2-beta-naphthylamide + H2O
-
 Mus musculus ?
-
 ?
benzyloxycarbonyl-Gly-Pro-4-methylcoumarin 7-amide + H2O
-
 Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 78000, SDS-PAGE Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
41
-
-
 Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
 Mus musculus

pH Range

pH Minimum pH Maximum Comment Organism
5.5 7.5
-
 Mus musculus