Literature summary for 3.4.21.26 extracted from

Klegeris, A.; Li, J.; Bammler, T.K.; Jin, J.; Zhu, D.; Kashima, D.T.; Pan, S.; Hashioka, S.; Maguire, J.; McGeer, P.L.; Zhang, J.
Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial and THP-1 cell neurotoxicity (2008), Glia, 56, 675-685.

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Activating Compound

Activating Compound	Comment	Organism	Structure
alpha-synuclein	plus interferon-gamma increases prolyl endopeptidase activity. Lipopolysaccharide, interferon-gamma or alpha-synuclein alone do not significantly upregulate prolyl endopeptidase enzymatic activity	Homo sapiens
interferon-gamma	combination of lipopolysaccharide or interferon-gamma plus interferon-gamma upregulates prolyl endopeptidase enzymatic activity. Lipopolysaccharide, interferon-gamma or alpha-synuclein alone do not significantly upregulate prolyl endopeptidase enzymatic activity	Homo sapiens
lipopolysaccharide	combination of lipopolysaccharide plus interferon-gamma upregulates prolyl endopeptidase enzymatic activity. Lipopolysaccharide, interferon-gamma or alpha-synuclein alone do not significantly upregulate prolyl endopeptidase enzymatic activity	Homo sapiens

Application

Application	Comment	Organism
medicine	inhibition of the enzyme may be a therapeutic approach to neurodegenerative disorders including Alzheimer and Parkinson diseases	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Boc-Asn-Phe-Pro-aldehyde	-	Homo sapiens
Z-Pro-Pro-aldehyde-dimethyl acetal	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-
endoplasmic reticulum	-	Homo sapiens	5783	-
extracellular	-	Homo sapiens	-	-
lysosome	-	Homo sapiens	5764	-
membrane	-	Homo sapiens	16020	-
mitochondrion	-	Homo sapiens	5739	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P48147	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
THP-1 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Z-Gly-L-Pro-4-nitroanilide + H2O	-	Homo sapiens	Z-Gly-L-Pro + 4-nitroaniline	-	?

Synonyms

Synonyms	Comment	Organism
prolyl endopeptidase	-	Homo sapiens

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Release 2023.1 (January 2023)