Any feedback?
Literature summary for 3.4.21.21 extracted from
- Recombinant factor VIIa, its clinical properties, and the tissue factor pathway of coagulation (2006), Mini Rev. Med. Chem., 6, 1111-1117.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| vitamin K | dependent on, activation cycle, overview | Homo sapiens |  |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the enzyme is clinically used to treat hemophilia, clinical trials, overview | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| genetic localization at 13q34, cloning from a liver gene library, expression in BHK cells with secretion to the medium | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | one FVIIa molecule binds 8 Ca2+ in the epidermal growth factor-like and the gamma-carboxyglutamic acid-rich domains | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50000 | - |
x * 50000, zymogen FVII, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Factor X + H2O | Homo sapiens | the enzyme is involved in the coagulation cascade, pathways, overview | Factor Xa + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | N-glycosylation at Asp145 and Asp322, and O-glycosylation | Homo sapiens |
| proteolytic modification | zymogen factor VII is activated by thrombin | Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant FVII zymogen from BHK cell medium | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Factor X + H2O | - |
Homo sapiens | Factor Xa + ? | - |
? | |
| Factor X + H2O | the enzyme is involved in the coagulation cascade, pathways, overview | Homo sapiens | Factor Xa + ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 50000, zymogen FVII, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| factor VIIa | - |
Homo sapiens |
| FVIIa | - |
Homo sapiens |
| vitamin K dependent clotting factor | - |
Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
