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Literature summary for 3.4.21.21 extracted from

  • Sutherland, M.R.; Friedman, H.M.; Pryzdial, E.L.
    Herpes simplex virus type 1-encoded glycoprotein C enhances coagulation factor VIIa activity on the virus (2004), Thromb. Haemost., 92, 947-955.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Herpes simplex virus 1 encoded glycoprotein C gC, 1000fold activity-enhancing effect in the absence of tissue factor and in the presence of 5 mM Ca2+ and 0.1 mM synthetic small unilamellar vesicles composed of 75% phosphatidylcholine and 25% phosphatidylserine Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
anti-gC antibody 20% inhibition Homo sapiens
anti-TF antibody 40% inhibition Homo sapiens
combination of the gC- and TF-specific antibodies 65% inhibition Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor X + H2O Homo sapiens
-
factor Xa
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-D-arginyl-glycyl-arginine-p-nitroanilide + H2O
-
Homo sapiens benzyloxycarbonyl-D-arginyl-glycyl-arginine + p-nitroaniline
-
?
factor X + H2O
-
Homo sapiens factor Xa
-
?

Synonyms

Synonyms Comment Organism
factor VIIa
-
Homo sapiens