Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q61955 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hippocampus | - |
Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | function of kallikrein 8 in regulating the expression of microtubule associated dendrite growth marker microtubule-associated protein (MAP2)c, dendrite architecture and protein kinase A (PKA)-CREB signaling. Knockdown of KLK8 via siRNA transfection in mouse primary hippocampal neurons or via intra-hippocampal administration of KLK8 antisense oligonucleotides in vivo reduces expression of MAP2c, dendrite length, dendrite branching and spine density. The KLK8-mediated MAP2c deficiency in turn inactivates protein kinase A, and downstream transcription factor phosphorylates CREB, leading to downregulation of memory-linked genes and consequent impaired memory consolidation | Mus musculus |