Literature summary for 3.4.21.118 extracted from

Konar, A.; Kumar, A.; Maloney, B.; Lahiri, D.; Thakur, M.
A serine protease KLK8 emerges as a regulator of regulators in memory Microtubule protein dependent neuronal morphology and PKA-CREB signaling (2018), Sci. Rep., 8, 9928 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q61955	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hippocampus	-	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	function of kallikrein 8 in regulating the expression of microtubule associated dendrite growth marker microtubule-associated protein (MAP2)c, dendrite architecture and protein kinase A (PKA)-CREB signaling. Knockdown of KLK8 via siRNA transfection in mouse primary hippocampal neurons or via intra-hippocampal administration of KLK8 antisense oligonucleotides in vivo reduces expression of MAP2c, dendrite length, dendrite branching and spine density. The KLK8-mediated MAP2c deficiency in turn inactivates protein kinase A, and downstream transcription factor phosphorylates CREB, leading to downregulation of memory-linked genes and consequent impaired memory consolidation	Mus musculus

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Release 2023.1 (January 2023)