Literature summary for 3.4.21.118 extracted from

Cerqueira, C.; Samperio Ventayol, P.; Vogeley, C.; Schelhaas, M.
Kallikrein-8 proteolytically processes human papillomaviruses in the extracellular space to facilitate entry into host cells (2015), J. Virol., 89, 7038-7052 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O60259	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
papillomavirus major capsid protein L1 + H2O	-	Homo sapiens	?	-	?

General Information

General Information	Comment	Organism
physiological function	during entry of human papillomaviruses into host cells, the major capsid protein L1 undergoes proteolytic cleavage during entry of the host cell. At least two proteolytic cleavages of L1 are observed, one of which is independent of the low-pH environment of endosomes and mediated by kallikrein-8. KLK8-mediated cleavage is crucial for further conformational changes exposing an important epitope of the minor capsid protein L2. KLK8-mediated cleavage of L1 likely facilitates access to L2, located in the capsid lumen, and potentially uncoating	Homo sapiens

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Release 2023.1 (January 2023)