Literature summary for 3.4.21.118 extracted from

Iinuma, S.; Kishibe, M.; Saito, N.; Igawa, S.; Honma, M.; Takahashi, H.; Bando, Y.; Yoshida, S.; Iizuka, H.; Ishida-Yamamoto, A.
Klk8 is required for microabscess formation in a mouse imiquimod model of psoriasis (2015), Exp. Dermatol., 24, 887-889 .

Search for more literature for 3.4.21.118

Application

Application	Comment	Organism
medicine	imiquimod-treated skin of wild-type mice shows characteristic neutrophil microabscess formation in the epidermis, which is markedly reduced in Klk8 knockout mice. Klk8 is crucial for microabscess formation in the upper epidermis, where Klk8 is significantly involved in IL-36 expression	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	localized both in cytoplasmic and intercellular areas	Mus musculus	5737	-
extracellular	localized both in cytoplasmic and intercellular areas	Mus musculus	-	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q61955	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
epidermis	upper epidermis	Mus musculus	-
skin	expression of Klk8 in the imiquimod-treated skin is significantly higher than that in untreated skin	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
KLK8	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	expression of Klk8 in the imiquimod-treated skin is significantly higher than that in untreated skin	up

General Information

General Information	Comment	Organism
physiological function	no statistically significant difference is observed in the number of Ki-67-positive keratinocytes between wild-type and Klk8 knockout mice, nor is epidermal thickness affected in Klk8 knockout mice. Topical application of imiquimod on the ear of wild-type mice results in increased ear thickness, which is significantly reduced in Klk8 knockout mice from day 5 post-treatment. The reduced ear swelling is mostly due to the decrease in dermal inflammatory cell infiltration and oedema rather than epidermal acanthosis	Mus musculus

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Release 2023.1 (January 2023)