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Literature summary for 3.4.21.118 extracted from

  • Shingaki, K.; Matsuzaki, S.; Taniguchi, M.; Kubo, T.; Fujiwara, T.; Yamamoto, A.; Tamura, H.; Maeda, T.; Ooi, K.; Matsumoto, K.; Shiosaka, S.; Tohyama, M.
    Molecular mechanism of kallikrein-related peptidase 8/neuropsin-induced hyperkeratosis in inflamed skin (2010), Br. J. Dermatol., 163, 466-475.
    View publication on PubMed
Search for more literature for 3.4.21.118

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
HaCaT cell
-
 Homo sapiens
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keratinocyte
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 Homo sapiens
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skin
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 Mus musculus
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stratum spinosum
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 Mus musculus
-

Synonyms

Synonyms Comment Organism
kallikrein-related peptidase 8
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 Mus musculus
kallikrein-related peptidase 8
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 Homo sapiens
neuropsin
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 Mus musculus
neuropsin
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus neuropsin is upregulated in the epidermis of sodium lauryl sulfate-treated mouse skin up
Homo sapiens skin inflammation increases KLK8/neuropsin expression in the stratum spinosum up

General Information

General Information Comment Organism
malfunction hyperkeratosis and acanthosis in sodium lauryl sulfate-stimulated skin are markedly inhibited in neuropsin knockout mice. Knockdown of KLK8/neuropsin decreases keratin 10 expression Mus musculus
malfunction knockdown of KLK8/neuropsin increases transcription factor activator protein-2alpha expression Homo sapiens