Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.118 extracted from

  • Scott, F.L.; Sun, J.; Whisstock, J.C.; Kato, K.; Bird, P.I.
    SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes (2007), J. Biochem., 142, 435-442.
    View publication on PubMed
Search for more literature for 3.4.21.118

Inhibitors

Inhibitors Comment Organism Structure
serpinB6 is a physiologically relevant inhibitor of hK8 in skin. SerpinB6 protects the intracellular compartment of keratinocytes from ectopic hK8 Homo sapiens
serpinB6
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm distributed in keratinocytes in the stratum spinosum and granulosum Homo sapiens 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
 immunoblotting Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
keratinocyte hK8 and serpinB6 are co-expressed in differentiated primary human keratinocytes Homo sapiens
-
keratinocyte interaction between murine serpinB6 and mK8 is at least 10fold faster than that observed for serpinB6 and hK8 Mus musculus
-
skin
-
 Mus musculus
-
skin
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Boc-Val-Pro-Arg-4-methylcoumaryl-7-amide + H2O
-
 Homo sapiens Boc-Val-Pro-Arg + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
hK8
-
 Homo sapiens
kallikrein-8
-
 Mus musculus
kallikrein-8
-
 Homo sapiens
KLK8
-
 Mus musculus
KLK8
-
 Homo sapiens
mK8
-
 Mus musculus
neuropsin
-
 Mus musculus
neuropsin
-
 Homo sapiens
PRSS19
-
 Mus musculus
PRSS19
-
 Homo sapiens