Cloned (Comment) | Organism |
---|---|
gene KLK6, genetic organization and structure of the kallikrein gene family, clustered on chromosome 19q13.3-q13.4 | Homo sapiens |
gene KLK8, genetic organization and structure of the kallikrein gene family, clustered on chromosome 19q13.3-q13.4 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | enzyme might be involved in ovarian cancer, brain damage and kindling epilepsy | ? | - |
? | |
polypeptide + H2O | Homo sapiens | - |
peptides | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O60259 | gene KLK8 | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys | substrate binding pocket contains an Asp residue | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
central nervous system | high expression level | Homo sapiens | - |
ovarian carcinoma cell | overexpression | Homo sapiens | - |
ovary | high expression level | Homo sapiens | - |
skin | high expression level | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme might be involved in ovarian cancer, brain damage and kindling epilepsy | Homo sapiens | ? | - |
? | |
polypeptide + H2O | - |
Homo sapiens | peptides | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ovasin | - |
Homo sapiens |
TADG14 | - |
Homo sapiens |