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Literature summary for 3.4.21.118 extracted from

  • Yousef, G.M.; Diamandis, E.P.
    The new human tissue kallikrein gene family: structure, function, and association to disease (2001), Endocr. Rev., 22, 184-204.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene KLK6, genetic organization and structure of the kallikrein gene family, clustered on chromosome 19q13.3-q13.4 Homo sapiens
gene KLK8, genetic organization and structure of the kallikrein gene family, clustered on chromosome 19q13.3-q13.4 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme might be involved in ovarian cancer, brain damage and kindling epilepsy ?
-
?
polypeptide + H2O Homo sapiens
-
peptides
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O60259 gene KLK8
-

Reaction

Reaction Comment Organism Reaction ID
cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys substrate binding pocket contains an Asp residue Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
central nervous system high expression level Homo sapiens
-
ovarian carcinoma cell overexpression Homo sapiens
-
ovary high expression level Homo sapiens
-
skin high expression level Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme might be involved in ovarian cancer, brain damage and kindling epilepsy Homo sapiens ?
-
?
polypeptide + H2O
-
Homo sapiens peptides
-
?

Synonyms

Synonyms Comment Organism
ovasin
-
Homo sapiens
TADG14
-
Homo sapiens