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Literature summary for 3.4.21.118 extracted from

  • Kato, K.; Kishi, T.; Kamachi, T.; Akisada, M.; Oka, T.; Midorikawa, R.; Takio, K.; Dohmae, N.; Bird, P.I.; Sun, J.; Scott, F.; Miyake, Y.; Yamamoto, K.; Machida, A.; Tanaka, T.; Matsumoto, K.; Shibata, M.; Shiosaka, S.
    Serine proteinase inhibitor 3 and murinoglobulin I are potent inhibitors of neuropsin in adult mouse brain (2001), J. Biol. Chem., 276, 14562-14571.
    View publication on PubMed
Search for more literature for 3.4.21.118

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of proneuropsin in Spodoptera frugiperda insect cells via baculovirus infection Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
murinoglobulin I 24% inhibition at enzyme-inhibitor ratio of 1:2; formation of a SDS-stable complex; i.e. MUG I Mus musculus
serine protease inhibitor-3 formation of a SDS-stable complex, bimolecular kinetics; from pyramidal neurons; slowly and tightly binding inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
polypeptide + H2O Mus musculus involvement in neural plasticity peptides
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q61955
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein enzyme contains N-glycosylation sites Mus musculus

Purification (Commentary)

Purification (Comment) Organism
recombinant from SF21 insect cells Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain expressed in the forebrain limbic area of adult brain Mus musculus
-
neuron in the hippocampal CA1-CA3 subfields Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
polypeptide + H2O
-
 Mus musculus peptides
-
 ?
polypeptide + H2O involvement in neural plasticity Mus musculus peptides
-
 ?
tert-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumaryl-7-amide + H2O
-
 Mus musculus tert-butyloxycarbonyl-Val-Pro-Arg + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
NP
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0008
-
 serine protease inhibitor-3 complex formation, pH 7.4, 37°C Mus musculus