Literature summary for 3.4.21.117 extracted from

Dong, Y.; Tan, O.L.; Loessner, D.; Stephens, C.; Walpole, C.; Boyle, G.M.; Parsons, P.G.; Clements, J.A.
Kallikrein-related peptidase 7 promotes multicellular aggregation via the alpha(5)beta(1) integrin pathway and paclitaxel chemoresistance in serous epithelial ovarian carcinoma (2010), Cancer Res., 70, 2624-2633.

Search for more literature for 3.4.21.117

Cloned(Commentary)

Cloned (Comment)	Organism
stable overexpression of KLK7-253 in SKOV-3 cells, leading to formation of multicellular aggregates, MCAs, that promote cell survival and chemoresistance, with involvement of KLK7 and integrin-regulated cell adhesion. KLK7-253 cells form MCAs invade into mesothelial cell monolayers	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	two different KLK7 transcripts, KLK7-253 and KLK7-181	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
ovary cancer cell	KLK7 is upregulated in epithelial ovarian carcinoma, expression of two different KLK7 transcripts, KLK7-253 and KLK7-181, simultaneously	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
kallikrein-related peptidase 7	-	Homo sapiens
KLK7	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	KLK7 is upregulated in epithelial ovarian carcinoma with high levels correlated with poor prognosis. Mechanism for association of high KLK7 levels with chemoresistance and poor prognosis for serous EOC patients by promotion of peritoneal dissemination and reinvasion via increased MCA and alpha5beta1 integrin-dependent cell adhesion	Homo sapiens

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Release 2023.1 (January 2023)