Inhibitors | Comment | Organism | Structure |
---|---|---|---|
LEKTI | LEKTI is expressed in stratum corneum and in stratum granulosum and is a reversible inhibitor encoded by the SPINK5 (serine protease inhibitor Kazal type 5) gene. LEKTI is a weak inhibitor toward KLK 7 but a much stronger inhibitor toward KLK5 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skin | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acidic sphingomyelinase + H2O | - |
Homo sapiens | ? | - |
? | |
beta-glucocerebrosidase + H2O | - |
Homo sapiens | ? | - |
? | |
corneodesmosin + H2O | KLK7 degrades corneodesmosomes CDSN, DSC1, and DSG1 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
kallikrein 7 | - |
Homo sapiens |
KLK7 | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
additional information | - |
enzyme shows optimal activity at neutral pH, and retains significant activity at acidic pH | Homo sapiens |
5.5 | - |
proteolysis of corneodesmosin | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000348 | - |
LEKTI | - |
Homo sapiens |