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Literature summary for 3.4.21.117 extracted from
- Formation of active IL-1 beta from pro-IL-1 beta catalyzed by stratum corneum chymotryptic enzyme in vitro (1997), Acta Derm. Venereol., 77, 203-206.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| polypeptide + H2O | Homo sapiens | - |
peptides | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| cleavage of proteins with aromatic side chains in the P1 position | enzyme is a chymotrypsin-like serine protease | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epithelium | keratinizing squamous | Homo sapiens | - |
| keratinocyte | - |
Homo sapiens | - |
| additional information | enzyme is specifically expressed in keratinizing squamous epithelia | Homo sapiens | - |
| stratum corneum | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| human pro-interleukin 1beta + H2O | several claevage sites | Homo sapiens | human interleukin beta1 + ? | product can be further degraded by the enzyme leading to its inactivation | ? | |
| human pro-interleukin 1beta + H2O | several claevage sites | Homo sapiens | human interleukin beta1 + ? | product is in the active form | ? | |
| human pro-interleukin 1beta + H2O | recombinant enzyme and substrate | Homo sapiens | human interleukin beta1 + ? | product can be further degraded by the enzyme leading to its inactivation | ? | |
| human pro-interleukin 1beta + H2O | recombinant enzyme and substrate | Homo sapiens | human interleukin beta1 + ? | product is in the active form | ? | |
| human pro-interleukin 1beta + H2O | substrate is in the inactive form | Homo sapiens | human interleukin beta1 + ? | product can be further degraded by the enzyme leading to its inactivation | ? | |
| human pro-interleukin 1beta + H2O | substrate is in the inactive form | Homo sapiens | human interleukin beta1 + ? | product is in the active form | ? | |
| polypeptide + H2O | - |
Homo sapiens | peptides | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SCCE | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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