Cloned (Comment) | Organism |
---|---|
cloning from keratinocyte library, DNA and RNA sequence determination and analysis, expression of the enzyme in its proform in murine C127 cells, enzyme activation by trypsin | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
polypeptide + H2O | Homo sapiens | - |
peptides | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P49862 | gene KLK7, RNA sequence | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | recombinant and native enzyme | Homo sapiens |
glycoprotein | enzyme contains 1 potential N-glycosylation site | Homo sapiens |
proteolytic modification | recombinant enzyme proform is activated by digestion with trypsin | Homo sapiens |
Purification (Comment) | Organism |
---|---|
recombinant and native enzyme | Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
cleavage of proteins with aromatic side chains in the P1 position | enzyme is a chymotrypsin-like serine protease | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epidermis | enzyme expression | Homo sapiens | - |
keratinocyte | enzyme expression | Homo sapiens | - |
additional information | enzyme expression in restricted to skin | Homo sapiens | - |
skin | - |
Homo sapiens | - |
stratum corneum | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | recombinant enzyme proform is activated by digestion with trypsin | Homo sapiens | ? | - |
? | |
polypeptide + H2O | - |
Homo sapiens | peptides | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SCCE | - |
Homo sapiens |